Gene Edited Pigs – Redefining the Future of Organ Transplantation presents a comprehensive and forward-looking exploration of pigs as one of the most versatile and translationally relevant biomedical models of the 21st century. Drawing upon advances in gene editing, xenotransplantation, and systems biology, the book systematically examines the anatomical, physiological, immunological, and molecular parallels between pigs and humans that underpin their growing importance in regenerative medicine and organ transplantation. The chapters traverse a wide scientific spectrum – from porcine xenografts, disease modeling, pharmacology, and toxicology to reproductive biotechnology, microbiome research, neuroscience, and biopharmaceutical production. The volume also contextualizes global scientific progress with a focused discussion on the requirements and strategic imperatives for augmenting pigs as
experimental systems in India. Designed as a definitive reference, the book integrates fundamental science with applied perspectives, making it equally valuable to researchers, clinicians, regulators, and advanced students engaged in translational biomedical research.

Key Features of the Book

• Holistic scientific coverage: Integrates xenotransplantation, regenerative medicine, immunology, microbiome science, neuroscience, and device safety using porcine systems as a unifying model.

• Strong translational focus: Highlights gene editing–enabled solutions to immunological rejection, disease transmission, and functional compatibility in organ transplantation.

• Relevance to policy and capacity building: Addresses infrastructural, regulatory, and scientific requirements for strengthening pig-based biomedical research in India.

• Authoritative reference resource: Structured chapters, extensive references, and an index make it suitable for academia, research institutions, and regulatory bodies.

• Abbreviations and Acronyms
• Comparative anatomy and Physiology of Pigs and Humans
• Xenotransplantation and Porcine Xenografts
• Porcine Biomedical and Disease Models
• Regenerative Medicine and Tissue Engineering in Porcine Systems
• Pharmacology and Toxicology in Porcine Systems
• Reproductive Biotechnology in Porcine Systems
• Immunology and Host–Pathogen Interaction in Porcine Systems
• Nutrition, Gut Health and the Microbiome in Porcine Experimental Systems
• Behaviour, Welfare and Neuroscience in Porcine Systems
• Pigs in Biopharmaceutical Production
• Use of Pigs in Safety Assessment of Cardiovascular and Implantable Medical Devices
• Requirements for Augmenting the Pig as an Experimental System in India
• Epilogue